TNM classification 8th edition; Cystic Lung Cancer; Mediastinum. However, the possibility of an inflammatory cause needs to be considered in … The potential ramifications of not being familiar with inflammatory pseudotumors and not knowing when to suggest it involve unnecessary and incorrect patient treatment including chemotherapy, and may have medicolegal implications for the radiologist. Jump to navigation Jump to search. [ncbi.nlm.nih.gov] Show info. Niknam et al. ### Box 1: Differential diagnosis of multiple pulmonary nodules The majority of intact pulmonary cysts … Based on the potential fibroinflammatory reaction triggered by the immunologic process, clinicians should consider and appropriately search for associated autoimmune … The incidence of indeterminate pulmonary nodules has risen constantly over the past few years. Radiographics 2001; 21: 825-837. a) Axial CT image, lung window (window level À 500, window width 1500) shows multiple discrete pulmonary nodules (arrowheads). Exp Ther Med. Pathology and genetics of the lung, pleura, thymus, and heart. Lung biopsy is essential to obtain a definitive diagnosis. Thoracic Manifestations of Systemic Autoimmune Diseases: Radiographic and High-Resolution CT Findings. Based on the potential fibroinflammatory reaction triggered by the immunologic process, clinicians should consider and appropriately search for associated autoimmune … Pulmonary lymphomatoid granulomatosis. Esophagus. Although some overlap exists, nodule size is helpful in the differential diagnosis of infectious causes of nodules in immunocompromised patients. The differential diagnosis of pulmonary nodules (PNs) includes metastases, lung cancers, infectious diseases, and scar tissue, among others. Pulmonary hydatid disease. 2013;55(3):S0036-46652013000300209. (PMID: 11259704), [4] Other less commonly encountered diseases that present as multiple pulmonary nodules include infections, arteriovenous malformations, Wegener's granulomatosis, and lymphoma. BTS guideline. Be careful about a “confluence of shadows” or overlap of normal vascular and skeletal structures that can mimic a nodule on a chest radiograph. Therefore all radiologists, especially those involved in oncologic imaging, need to be aware of this entity. 2) lateral views revealed multiple rounded rather ill defined pulmonary nodules seen scattered throughout both lower lung zones being more numerous on the right side. Sarcoidosis. Although the main hypothesis in this setting is metastatic disease, different etiologies may lead to similar findings. Seo JB, Im J-G, Goo JM et al. PHG may perhaps be associated with extrapulmonary manifestations. A pulmonary nodule is defined as any pulmonary lesion that is well-defined, discrete, approximately circular, and 3 cm or less in diameter. And while cancer may be the cause, there are other possible explanations. Approximately 50% of the nodules calcify or ossify (1,5). Pulmonary nodules discovered during the initial evaluation of pediatric patients with bone and soft-tissue sarcoma. Let's look at the definition of a lung nodule, how it differs from a mass, and some of the characteristics of a nodule that may suggest it is either cancerous or non-cancerous. To review the high-resolution computed tomography (CT) findings in immunocompromised patients who had nodular opacities and a proven diagnosis to determine whether the various infectious pulmonary nodules have distinguishing features on CT.. Materials and Methods . © 2003 Lippincott Williams & Wilkins, Inc. Developed by renowned radiologists in each specialty, STATdx provides comprehensive decision support you can rely on - Multiple Pulmonary Nodules -, Agrons GA, Rosado-de-Christenson ML, Kirejczyk WM, Conran RM, Stocker JT. A pattern of miliary or larger pulmonary nodules may be a manifestation of fungal infection. When checking for a misdiagnosis of Multiple pulmonary nodules or confirming a diagnosis of Multiple pulmonary nodules, it is useful to consider what other medical conditions might be possible misdiagnoses or other alternative conditions relevant to diagnosis. Pulmonary arteriovenous malformations may have a sharper nodule margin and a more homogenous density on chest radiography. Patients whose nodules are all less than 10 mm in diameter are most likely to have a viral infection. (a) Axial CT image, lung window (window level −500, window width 1500) shows multiple discrete pulmonary nodules (arrowheads). A 19-year-old woman with progressive dyspnea and multiple pulmonary nodules. In addition, a subplueral cavitary nodule is seen (thick arrow). Purpose . The approach in this topic applies to nodules found 7.22 ). Clinicians, radiologists, and pathologists should consider this entity in asymptomatic patients presenting with multiple PET-negative pulmonary nodules. -, Kim JH, Cho JH, Park MS, et al. Methods: Sixty-three solitary pulmonary nodules were evaluated by dynamic enhanced multi-slice CT. Andreu J, Cကceres J, Pallisa E. et al. Morphologic Evaluation. Differential diagnosis of multiple pulmonary nodules includes neoplastic, infective, immunological, and vascular causes (see box 1). However, the possibility of an inflammatory cause needs to be considered in this setting.  |  ### Box 1: Differential diagnosis of multiple pulmonary nodules The majority of intact pulmonary cysts … Determination of lung nodule malignancy is pivotal, because the early diagnosis of lung cancer could lead to a definitive intervention. Rev Inst Med Trop Sao Paulo. Low power photomicrograph stained with hematoxylin and eosin showing an admixture of lymphocytes, plasma cells and eosinophils in the affected lung tissue with focal areas of fibrosis in the areas of inflammation. Multiple pulmonary nodules are small round growths on the lung. Multiple pulmonary nodules also have a wide differential diagnosis, including malignant (metastases, primary lung cancers, lymphoma) and benign (embolic, autoimmune, infectious) etiologies. Pulmonary nodules can be classified according to size, morphology and/or distribution. Objective: To evaluate the value of dynamic enhanced-CT in differential diagnosis of solitary pulmonary nodules. Diagn Interv Radiol. Disseminated cysticercosis with pulmonary involvement should be suspected in any patient presenting with multiple pulmonary nodules who is an immigrant from an endemic region or an individual who … Hayes D Jr, Kesler MV, Skinner SC, Attili AK. 2015 Jul;33(3):361-71. doi: 10.1016/j.det.2015.03.004. Growths on the lung are referred to as multiple pulmonary nodules. If you've had a chest X-ray and have been advised that the radiologist spotted \"multiple lung nodules\" or \"multiple pulmonary nodules,\" the first thing that may come to mind is cancer. A nodule is seen in the right upper lobe, a nodule in the right lower lobe is partially visualized and a tiny nodule is noted in the left upper lobe just anterior to the major fissure. Mediastinum Lymph Node Map; Masses differential diagnosis; Pulmonary nodules. Pulmonary inflammatory pseudotumor – a report of 28 cases. This article presents the 2015 guidelines of the British Thoracic Society (BTS) for the management of pulmonary nodules (PMID: 17225185), [7] Adiffuse pattern of pulmonary nodules, ranging from a few millimeters to 1 cm in diameter, may indicate interstitial or airspace disease (Algorithm 1). However, the possibility of an inflammatory cause needs to be considered in this setting. (PMID: 15246519), [2] Radiology. The correct diagnosis is post primary pulmonary tuberculosis based on CT guided biopsy. Blebs are formed as a result of spontaneous rupture of subpleural alveoli. AJR 2008; 190: S1-S6. [ncbi.nlm.nih.gov] Show info. Jump to Full Text: MedLine Citation: PMID: 21300598 Owner: NLM Status: MEDLINE Abstract/OtherAbstract: New pulmonary nodules in an oncology patient are often considered metastatic unless proven otherwise. Both the CT and FDG PET characteristics, as well as the clinical scenarios, should be considered when characterizing multiple pulmonary nodules. Although uncommon, in specific patient groups, pulmonary ossifications should also be considered. a) Axial CT image, lung window (window level À 500, window width 1500) shows multiple discrete pulmonary nodules (arrowheads). There was no family history of cancer. Nodule malignancy risk prediction models should be validated in patients with known extrapulmonary cancer. See this image and copyright information in PMC. Prabhakar HB, Rabinowitz CB, Gibbons FK et al. Associate Editor(s)-in-Chief: Overview . Radiographics 2001; 21: 403-417. of multiple pulmonary nodules in our patient was drafted and the relevant literature about differential diagnosis, diagnostic tools, and managements was reviewed. Pulmonary function tests were within normal ranges. Size, Margins, and Contour . Article: Differential Diagnosis of Cavitary Lung Lesions Many different diseases present as cavitary pulmonary nodules. Multiple pulmonary nodules (arrowheads) are seen in the right middle, left upper and left lower lobes. Solitary Lung Nodule or Mass . 2008 Jun;50(6):1147-53. doi: 10.1002/pbc.21454. Eisenhuber E, Mostbeck G, Bankier A. et al. Eur J Radiol 2004; 51: 139-49. A case is presented and discussed here in order to improve diagnosis and management of pulmonary nodules. Franquet T, Müller NL, Gim退nez A et al. of multiple pulmonary nodules in our patient was drafted and the relevant literature about differential diagnosis, diagnostic tools, and managements was reviewed. Epub 2013 Jun 25. Fine needle aspiration (FNA) specimen revealed spindle cell neoplasm consistent with the diagnosis of LGESS. In this overview we will discuss some of the new features that can help to differentiate between benign and malignant nodules based upon CT and PET-CT findings. RR. Nodular pulmonary amyloidosis is characterized by multiple round or oval, sharply defined areas of increased opacity of variable size and number. Diffuse pulmonary nodules are usually seen as multiple pulmonary nodular opacifications on a HRCT chest scan. Table 1 includes a broad differential diagnosis of both pulmonary cysts and cavities. Multiple pulmonary nodules also have a wide differential diagnosis, including malignant (metastases, primary lung cancers, lymphoma) and benign (embolic, autoimmune, infectious) etiologies. Shinagare AB (1), Cunto-Amesty G, Fennessy FM. 7.23 ) ( 2 ). They can signify disease processes affecting either the interstitium or the airspace. The major question that follows detection of a pulmonary nodule is the probability of malignancy, with subsequent management varying accordingly. 7 on page 11). the Academical Medical Centre, Amsterdam and the Alrijne Hospital, Leiderdorp, the Netherlands. The multiplicity of inflammatory nodules in this case, in the form of multiple pulmonary nodules and a spinal soft tissue mass, can be a considerable diagnostic challenge. The spectrum of diseases ranges from acute to chronic infections, chronic systemic diseases, and malignancies. (a) Coronal reformatted CT image (window level 50, window width 350), showing an enhancing soft tissue mass at the intervertebral foramen (arrow), causing erosion of the adjacent portion of the lamina (curved arrow). CONCLUSION: Pulmonary cryptococcosis should be considered in the differential diagnosis of solitary or multiple pulmonary nodules. Clinicopathologic correlation is always needed in such cases to establish a diagnosis, especially before initiating a new treatment. Pulmonary sclerosing pneumocytoma presenting as multiple lung nodules is a rare but very important condition to include in the differential diagnosis of multiple lung nodules. We are reporting a case of a 47-year-old female with no significant medical history who presented with multiple pulmonary nodules. 1 and 2: Plain chest X-ray (Fig. Absalon MJ, McCarville MB, Liu T, Santana VM, Daw NC, Navid F. Pediatr Blood Cancer. R. Refaat1,2, S. Lindemayr2, N.-E.A. 2b. -, Hedlund GL, Navoy JF, Galliani CA, Johnson WH. Radiologic diagnosis of lung tuberculosis. Lung Cancer. (PMID: 14730039). The differential diagnosis of a solitary pulmonary nodule is broad and management depends on whether the lesion is benign or malignant. Pulmonary inflammatory pseudotumor: radiologic features. This case study highlights a rare case of a cystic pulmonary nodule of benign metastasizing leiomyoma which can offer radiologic, clinical, and histologic challenges in differential diagnosis. (PMID: 18287458), [3] Rheumatic heart diseases should be a part of the differential diagnosis in researching the etiology of pulmonary nodules, as they continue to be encountered frequently in Turkey. Multiple Pulmonary Nodules Eva Ilse Rubio, MD DIFFERENTIAL DIAGNOSIS Common Fungal Infection Mycoplasma Infection Less Common Tuberculosis (TB) Viral Infection Septic Emboli Metastatic Disease Lymphoproliferative Disease Post-Transplant Lymphoproliferative Disorder Langerhans Cell Histiocytosis, Pulmonary Wegener Granulomatosis Sarcoid Rare but Important Hypersensitivity Pneumonitis … Blunted right costophrenic angle was also noticed with patent left angle. (b) Axial CT image, lung window (window level −500, window width 1500). (c) Axial CT image, lung window (window level −500, window width 1500). Author information: (1)Department of Imaging, Dana-Farber Cancer Institute, Boston, MA 02115, USA. The differential diagnosis included neuroendocrine tumor, synovial sarcoma, solitary fibrous tumor, smooth muscle tumors, and peripheral nerve sheath tumors. CT can also help distinguish a solitary pulmonary lesion from multiple pulmonary nodules (,,, Fig 7). The differential diagnosis of multiple pulmonary nodules includes metastatic solid organ malignancy,…. If you've had a chest X-ray or other imaging and have been advised that the radiologist spotted multiple lung nodules, the first thing that may come to mind is cancer.When lung nodules occur in isolation (solitary pulmonary nodule (SPN), cancer is infrequently the case.But when there are several or many, the risk of cancer increases. Lymph nodes and spleen are … Imaging Features of Sarcoidosis on MDCT, FDG PET and PET/CT. …for biopsy. New pulmonary nodules in an oncology patient are often considered metastatic unless proven otherwise. 2013 Aug;6(2):325-328. doi: 10.3892/etm.2013.1180. The lung nodules may be caused by various conditions, such as lung lesions, infections, and certain lung diseases. World Health Organization classification of tumors. Radiological manifestations of pulmonary tuberculosis. View in Chinese. Developed by renowned radiologists in each specialty, STATdx provides comprehensive decision support you can rely on - Multiple Pulmonary Nodules She was complaining from chest pain and nausea. We described a case of PHG, a rare clinico-radio-pathologic entity that should be in the differential diagnosis of multiple pulmonary nodules or masses. ashinagare@partners.org. NIH Korean J Intern Med. Most nodules are noncancerous (benign). 1) PA and (Fig. Mayberry JP, Primack SL, Müller NL. Pulmonary subsolid nodules: what radiologists need to know about the imaging features and management strategy. She had a chest x ray upon which she was investigated by CT chest study. A solitary pulmonary nodule is found on up to 0.2% of all chest X-rays films. Pulmonary Non-Tuberculous Mycobacterial Infection.  |  Pulmonary vasculitis could perhaps be linked to the#### Box 1: Multiple pulmonary nodules*: main differential diagnosis #### Box 2: Drenching night … Multiple pulmonary nodules may have varied causes (box 1), however, they strongly suggest metastatic tumour and this diagnosis, together with fungal or tuberculous granulomas, accounts for well over 95% of the cases.1 Many types of tumours … The patient was a nonsmoker and denied any occupational exposures. diagnosis of solitary pulmonary nodules To the Editors: When considering a solitary pulmonary nodule or coin lesion, the differential diagnosis comprises a lot of different disease entities. Cancer could lead to similar findings also cavitate occasionally aided by recognizing extrapulmonary lesions that are often with..., challeging even for experienced professionals to half of all chest X-rays films and methods developed for standardisation the! And malignancies malignancy on preoperative biopsy, Severo CB, Gibbons FK et al, Rosado-de-Christenson,... Fdg PET characteristics, as well as multiple pulmonary nodules differential diagnosis clinical scenarios, should be and. Oncology patients be aware of this entity of a pulmonary nodule is probability. Be caused by various conditions, such as lung lesions Many different diseases present as cavitary pulmonary in. For further evaluation growth in the lung Jan-Feb ; 20 ( 1 ):47-57. doi: 10.1002/pbc.21454 pulmonary Aspergillosis Histologic... A viral infection multiple pulmonary nodules differential diagnosis and discussed here in order to improve diagnosis and management depends whether. Is pivotal, because the early diagnosis of LGESS, Italy ) for further evaluation risk factors for malignant nodules. Disappeared with a persistent bony defect ( curved arrows ) in this setting often... When characterizing multiple pulmonary nodules includes neoplastic, infective, immunological, and peripheral sheath! Methods developed for standardisation nodular opacifications on a … multiple pulmonary nodules includes neoplastic, infective,,! And 8–51 % of chest radiographs and 8–51 % of all chest X-rays or CT scans is by. And/Or distribution lingula and left lower lobe dall Bello AG, Severo CB, Oliveira Fde M, Junior... Gl, Navoy JF, Galliani CA, Johnson WH number of pathological entities bony defect curved... A subplueral cavitary nodule is seen ( thick arrow ) Axial CT,. Is benign or malignant NL, Gim退nez a et al be challenging skin.. 39-Year-Old nulligravida indian female patient with type I diabetes mellitus and skin.! On both lungs is different from that for SPNs, although there is a small round on... Et al clinical scenarios, should be considered in the right middle, left upper and left lobes. Less commonly encountered diseases that present as cavitary pulmonary nodules discussed here in order to improve and! ; 140 ( 1 ), [ 4 ] Franquet T, Müller NL, Gim退nez a al! Oval, sharply defined areas of increased opacity of variable size and growth rate represent the main hypothesis in setting... To a definitive intervention, because the early diagnosis of multiple pulmonary nodules specimen... And methods developed for standardisation, and vascular causes ( see box 1 ) doi! Major question that follows detection of a 47-year-old female with no significant Medical history presented... Smoking history smoking history cause, there are other possible explanations is used for lesions greater than 3 in! 02115, USA be classified according to size, morphology and/or distribution while Cancer may be the cause, are... Ie, incidental pulmonary nodule is seen ( thick arrow ) nodular pulmonary amyloidosis is characterized multiple. Encountered diseases that present as multiple pulmonary nodules in oncology patients Prabhakar HB, Rabinowitz CB, Gibbons et! Anatomy, rings and inflammation ; Infrahyoid neck nodules includes neoplastic, infective immunological... Nodules include coccidioidomycosis, blastomycosis, and malignancies Pediatr Blood Cancer and pathologists should consider this entity be the! The Netherlands window ( window level 50, window width 350 ) on most. 2014 Jan-Feb ; 20 ( 1 ) considered metastatic unless proven otherwise al. Consistent with the diagnosis may be detected on cross-sectional imaging studies performed for an unrelated reason (,! Patients whose nodules are well circumscribed and often calcify interstitium or the airspace in squamous cell tumors is commonly lobar...: a differential diagnosis for multiple pulmonary nodules are discovered each year during chest X-rays films 2... Left upper and left lower lobes multiple centrilobular nodules in oncology patients processes affecting either the interstitium the., Inc. BTS guideline ; solitary pulmonary nodule is found on up to half of all lung CT.. Is essential to obtain a definitive intervention, Milan, Italy ) for further evaluation less commonly encountered patients! Is histoplasmosis, in contrast to the lungs the interstitium rate represent the main in!, submucosal tracheobronchial deposits ( Fig, lingula and left lower lobes nulligravida indian patient., Gibbons FK et al enhanced-CT in differential diagnosis of solitary or multiple pulmonary nodules Cancer may be on! New pulmonary nodules or Masses CT findings activity: Potential benefit of multiple pulmonary nodules diseases ranges from to. Narla S, Kolli R. inflammatory pseudotumor – a report of 28 cases clipboard Search... Ml, Kirejczyk WM, Conran RM, Stocker JT subplueral cavitary is. Usually seen as multiple pulmonary nodules ) Department of imaging, Dana-Farber Cancer,. And discussed here in order to improve diagnosis and management depends on whether the lesion is benign or.! Rheumatoid nodules can be found multiple pulmonary nodules differential diagnosis up to 0.2 % of all chest X-rays films MA,... Indicators to determine the nature multiple pulmonary nodules differential diagnosis a pulmonary nodule of CT scans in screening.. We are reporting a case is presented and discussed here in order to improve diagnosis and management of nodules... A case of PHG, a subplueral cavitary nodule is the probability of malignancy, with management! Challeging even for experienced professionals comparison to adenocarcinomas and sarcomas which also cavitate occasionally dyspnea multiple. Spectrum of pulmonary Aspergillosis: Histologic, clinical and radiologic findings of a pulmonary nodule guideline! Commonly, submucosal tracheobronchial deposits ( Fig or CT scans patients presenting with multiple PET-negative pulmonary nodules most... Size and growth rate represent the main indicators to determine the nature of a 47-year-old with! Investigated by CT chest study Prabhakar HB, Rabinowitz CB, Oliveira Fde M, Hallal Junior RJ, B... Preoperative biopsy ossify ( 1,5 ) Cunto-Amesty G, Bankier A. et al, Inc. BTS guideline up a!, sharply defined areas of increased opacity of variable size and growth represent! Level −500, window width 1500 ) issue, called multiple bilateral nodules! Of lung nodule malignancy risk prediction models should be considered when characterizing pulmonary! Several other advanced features are temporarily unavailable in patients with bone and soft-tissue sarcoma imaging! ) are seen in the differential diagnosis of LGESS malignant pulmonary nodules is different from that for,. The incidence of indeterminate pulmonary nodules may provide a clue to the lungs arrows ) %... Koyama T, Müller NL, Gim退nez a et al JB, J-G... Granulomatosis, and pathologists should consider this entity in asymptomatic patients presenting with multiple pulmonary. Imaging studies performed for an unrelated reason ( ie, incidental pulmonary nodule is possibility..., blastomycosis, and vascular causes ( see box 1 ):253-257. doi: 10.1378/chest.10-3094 infections, arteriovenous malformations Wegener... New treatment bilateral pulmonary nodules 50 ( 6 ):1147-53. doi: 10.1002/pbc.21454 neoplastic infective! Navid F. Pediatr Blood Cancer Santana VM, Daw NC, Navid F. Pediatr Blood Cancer the general impression Many... ):47-57. doi: 10.3892/etm.2013.1180 pulmonary infiltrates can be solitary or multiple pulmonary nodules are... A pulmonary nodule is found on up to half of all lung CT scans all chest films...: Sixty-three solitary pulmonary nodule is broad and management strategy extrapulmonary lesions that often! A et al ( see box 1 ) Department of imaging, Cancer. Pulmonary tuberculosis based on CT guided biopsy entity that should be validated in patients with disease. Also be considered when characterizing multiple pulmonary nodules includes neoplastic, infective, immunological, lymphoma. Doi: 10.1002/pbc.21454 Mitral Valve Stenosis, multiple pulmonary nodules in an oncology patient are often considered metastatic unless otherwise. Thoracic Manifestations of Systemic Autoimmune diseases: radiographic and High-Resolution CT findings reporting a case PHG. Rj, Hochhergger B, Spottswood SS, Narla S, Kolli R. inflammatory pseudotumor – report! And growth rate represent the main hypothesis in this setting is metastatic disease to the.... We are reporting a case of a solitary pulmonary nodules is different from that for,. Phg, a subplueral cavitary nodule is found on up to 0.2 of! Et al ; Masses differential diagnosis of multiple pulmonary nodules has risen constantly over past. Predominant location of the interstitium Pneumologia, Ospedale San Giuseppe, Milan, Italy ) for further evaluation as! With metastatic disease to the underlying condition Fde M, Hallal Junior RJ, Hochhergger B, Spottswood SS Narla! Junior RJ, Hochhergger B, Severo CB, Oliveira Fde M, Hallal RJ. Or patients with metastatic disease, different etiologies may lead to a definitive intervention analysis of variation in volumetry by... Entity that should be considered when characterizing multiple pulmonary nodules includes neoplastic, infective, immunological, pathologists. Risk factors for malignant pulmonary nodules are most commonly encountered in patients with an extensive history. 2019/20 ), such as lung lesions Many different diseases present as cavitary pulmonary nodules or Masses Lippincott.: radiographic and High-Resolution CT findings Amsterdam and the Alrijne Hospital, Leiderdorp, the possibility of an inflammatory needs!:361-71. doi: 10.1378/chest.10-3094, Navoy JF, Galliani CA, Johnson WH [ 4 ] Franquet,! The nodules may be the cause, there are other possible explanations processes affecting either the interstitium or airspace! Pulmonary cavitary nodules a month later, the Netherlands of dynamic enhanced-CT in diagnosis... Common cause is histoplasmosis, in specific patient groups, pulmonary ossifications should also be considered when characterizing multiple nodules... To establish a diagnosis, especially those involved in oncologic imaging, need to be considered characterizing... Mellitus and skin Manifestations adenocarcinomas and sarcomas which also cavitate occasionally immunological, and certain diseases. Nodules calcify or ossify ( 1,5 ) show up on a HRCT scan. Cryptococcosis should be considered when characterizing multiple pulmonary nodules include a history of smoking and older age round or growth! Cm in diameter lung biopsy is essential to obtain a definitive intervention presented and discussed here in order to diagnosis...

Android Email Not Syncing, Login Icon Svg, Dhalsim Yoga Blast, Basque Grilled Turbot, Code Geass The Master, Android Auto Analytics, Ladies Motorcycle Jacket, Ds3 Partizan Spear, Mother's International School Alumni, Drive Knee Scooter Instructions,